The chances of men getting an erectile issue are high if they are sufferings from any possible health issues. Thus there can be a number of factors that can lead to causing erectile dysfunction. This is a condition where the person is not able to maintain an erection. Along with affecting the physical health of the person this condition also affects the mental condition of the person. Suffering from erectile dysfunction can also affect the relation of the person with their partners. Thus the use of Viagra for ED is very important in improving the condition of the person. The action of the medicine is through targeting the bloodstream of the person. Therefore buy Viagra online and treat the condition of erectile dysfunction. The causes of erectile dysfunction The main factors that cause erectile dysfunction in men are diabetes, metabolic disorder, anxiety, and blockage in the blood vessel of the person. It is seen that diabetes is one of the most common factors that cause impotence in people. Mostly after a few years of diagnosis of the condition, it is seen that the person suffers from erectile dysfunction. This is mostly because of the reason that diabetes affects the blood vessel of the person. As one of the most important factors that are needed to maintain an erection is a good flow of blood. Thus also having any kind of blockage in the blood vessel of the person can cause erectile dysfunction in people. Having metabolic dysfunction leads to increasing the blood pressure of the person thus resulting in impotence in people. Another medical condition that can accelerate the chances of getting an erectile dysfunction is having a heart condition, people with high cholesterol and obesity. Thus the use of Viagra for ED is very helpful in treating the condition right. The history of Viagra for ED The compound which is very important in the formulation of the medicine is sildenafil. This compound was first synthesized by a group of the pharmaceutical chemist who was working at Pfizer. The compound was initially used to study its effect to treat hypertension in people. It was initially planned to treat angina pectoris. The first clinical trial that was conducted in the Morriston hospital, it was seen that in phase 1 of the clinical trial was done under the direction of Ian Osterloh. The first trial suggests that the drug has very little effect on angina. However, it showed a major improvement in people suffering from erectile dysfunction. Thus Pfizer decided to market the medicine for impotence. The drug Viagra for ED was patented in the year 1996. It was approved for the use of erectile dysfunction by the food and the drug administration in the year of 1998. Viagra for ED became the first oral treatment that was being approved to treat impotence in men. And soon the medicine became a great success. The action of Viagra for ED in men The key compound that is used in the making of the medicine is sildenafil that is very important to protect the cyclic guanosine monophosphate (cGMP) from dehydration. The cGMP specific phosphodiesterases type 5 that are present in the corpus cavernosum. The nitric oxide is present in the body only when the person is stimulated. This nitric oxide then binds to the guanylate cyclase receptor that results in the increased in the level of the cGMP in the person. this, therefore, helps in relaxation of the smooth muscle of the intimal cushions of the helicine arteries. This smooth muscle relaxation, therefore, leads to vasodilation. It also increases the flow of blood into the spongy tissue of the organ.
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